Adenosine Deaminase Activity in Type-2 Diabetes Mellitus – An Independent Marker of Glycemic Status and Stimulator of Lipid Peroxidation

Abstract

Diabetes mellitus is a major worldwide health problem leading to markedly increased mortality and serious morbidity. Literature demonstrates high Adenosine deaminase activity in Type 2 diabetes mellitus than in non- diabetics. This study aims to correlate the association of Adenosine deaminase with dyslipidemia and HbA1C of Type 2 diabetes mellitus patients. A total 140 subjects were taken for study. 60 subjects act as controls (group-A) and 80 type 2 diabetic patients were selected by applying New American Diabetes Association guidelines. Cases were divided into two groups B (n=65 with HbA1C < 10%) and Group-C (n=15 with HbA1C 10%). An elevation of serum Adenosine deaminase was found in diabetic subjects as compared to controls. Adenosine deaminase activity is found to be higher in Group B and Group C. The correlation between Adenosine deaminase and HbA1C is positive and significant in both Group B(r=0.88123; p<0.0001) and C (r=0.972413 p<0.0001), but with dyslipidemia, it is negative in Group B (r=-0.78807; P<0.0001) and non-significant in Group C (r=0.3328; p=0.0035). Adenosine deaminase is elevated in Type 2 diabetes mellitus and can be considered as an independent marker of glycemic status and stimulator of Lipid peroxidation in this population.