Solid dispersion as a formulation strategy: A mini review

Pravinkumar Patel

Abstract


Oral route has been the most preferred route for administration of drug. However, in recent years majority of new drug candidates exhibit poor aqueous solubility for oral administration and hence pose a challenge for the formulation scientist [1]. Dissolution and/or permeation across the gastrointestinal membrane are the rate limiting step for oral absorption of drugs. Majority of the drugs belong to Class II of Biopharmaceutical Classification System (BCS). For these drugs, dissolution is the sole rate limiting step in oral absorption [2]. The current review lightens the advantages of the solid dispersion and discusses the production techniques, types of solid dispersion, and methods to choose a suitable carrier. Also, the common characterization techniques are explained. This mini review would help the readers understand the overall concept of solid dispersion as a drug delivery system.

Keywords


solid dispersion, solubility, drug delivery systems; amorphous; crystalline; review

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